OUES from submaximal cardiopulmonary exercise

Abstract Introduction Cardiopulmonary exercise testing (CPEX) provides valuable diagnostic and prognostic cardiopulmonary function data. However, in clinical setting a maximal test is not always achievable. The Oxygen Efficiency Uptake Slope (OUES) has been proposed as possible submaximal measure of it remains relatively stable during the final quartile test. This study explored validity OUES surrogate marker for event Methods Four groups subjects [128 healthy controls (73 M), 44 asymptomatic hypertensive (HT) patients (26 67 adult cardiac congenital heart disease (ACHD) (44 M) 35 Heart Failure with preserved Ejection Fraction (HFpEF) (10M) patients] were recruited after informed consent. All underwent assessment, resting ECG, blood pressure spirometry prior to treadmill CPEX volitional exhaustion respiratory exchange ratio (RER) at least 1.1 using same protocol. Peak VO2 (ml/min) was recorded from last 5s (RER=1.1) calculated complete truncated (RER=0.9) gas linear relationships between absolute peak data assessed Pearson's correlation coefficient. Subsequently, two correlations obtained each patient group compared. Statistical significance set p<0.01. Results Mean 95% confidence intervals males females decile life examined 4 subject are shown Figure. values achieved significantly lower when matched age sex compared participants (HT p=0.006, ACHD p<0.001 HFpEF p<0.001). In all there good RER (healthy volunteers r=0.910, p<0.001, HT r=0.899, r=0.816, r=0.846, Correlations inferior 0.9 r=0.74, r=0.780, r=0.651, r=0.817, vs different only (p=0.001, Z-score = −4.649), but (p=0.05, −1.909), (p=0.04, −2.080) or (p=0.7, −0.377) patients. Conclusion Our support use an 1.1, especially patients, whom can often be difficult achieve exercise. Funding Acknowledgement Type funding sources: None.